PCORnet, the National Patient-Centered Clinical Research Network, is a PCORI-funded initiative with the goal of developing infrastructure to enable patient-centered comparative effectiveness research (CER) to be conducted faster and more efficiently. We conducted a webinar on 12/14 to explore the ways in which the PCORnet data infrastructure might be enhanced for additional integration and collection of patient-reported outcomes (PROs), as well as potential opportunities to collect patient-generated health data (PGHD).